Monoclonal gammopathy of renal significance (MGRS)

Nasr SH, Royal V, Best Rocha A, Buttner-Herold M, Roufosse C, Bridoux F, et al. Renal Pathology Society/International Kidney and Monoclonal Gammopathy Research Group consensus on pathologic definitions and terminology of monoclonal gammopathy-associated kidney lesions. Kidney Int. 2025;108(2):184-93. PMID: 40280412.

Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D'Agati VD, et al. The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol. 2019;15(1):45-59. PMID: 30510265 Publisher correction Nat Rev Nephrol. 2019;15(2):121. PMID: 30568288.

Sirac C, Herrera GA, Sanders PW, Batuman V, Bender S, Ayala MV, et al. Animal models of monoclonal immunoglobulin-related renal diseases. Nat Rev Nephrol. 2018;14(4):246-64. PMID: 29456245.

Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, et al. Diagnosis of monoclonal gammopathy of renal significance. Kidney Int. 2015;87(4):698-711. PMID: 25607108.

Fermand JP, Bridoux F, Kyle RA, Kastritis E, Weiss BM, Cook MA, Drayson MT, Dispenzieri A, Leung N; International Kidney and Monoclonal Gammopathy Research Group. How I treat monoclonal gammopathy of renal significance (MGRS). Blood. 2013 Nov 21;122(22):3583-90. doi: 10.1182/blood-2013-05-495929. Epub 2013 Oct 9.Review. PMID: 24108460.

Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group. Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood. 2012 Nov 22;120(22):4292-5. doi: 10.1182/blood-2012-07-445304. Epub 2012 Oct 9. Review. PMID: 23047823.

AKI and Myeloma Kidney

Royal V, Leung N, Troyanov S, Nasr SH, Ecotiere L, LeBlanc R, et al. Clinicopathologic predictors of renal outcomes in light chain cast nephropathy: a multicenter retrospective study. Blood. 2020;135(21):1833-46. PMID: 32160635.

Hutchison CA, Blade J, Cockwell P, Cook M, Drayson M, Fermand JP, Kastritis E,Kyle R, Leung N, Pasquali S, Winearls C; International Kidney and MonoclonalGammopathy Research Group. Novel approaches for reducing free light chains inpatients with myeloma kidney. Nat Rev Nephrol. 2012 Feb 21;8(4):234-43. doi:10.1038/nrneph.2012.14. Review. PMID: 22349488.

Hutchison CA, Batuman V, Behrens J, Bridoux F, Sirac C, Dispenzieri A, HerreraGA, Lachmann H, Sanders PW; International Kidney and Monoclonal GammopathyResearch Group. The pathogenesis and diagnosis of acute kidney injury in multiplemyeloma. Nat Rev Nephrol. 2011 Nov 1;8(1):43-51. doi: 10.1038/nrneph.2011.168.Review. PMID: 22045243.

Renal transplant in patients with monoclonal gammopathies

Murakami N, Blosser CD, Webber AB, Gupta G, Singh N, Boppana S, et al. Management recommendations for kidney transplantation in patients with plasma cell dyscrasia. Kidney Int. 2025. PMID: 40738478.

Havasi A, Heybeli C, Leung N, Angel-Korman A, Sanchorawala V, Cohen O, et al. Outcomes of renal transplantation in patients with AL amyloidosis: an international collaboration through The International Kidney and Monoclonal Gammopathy Research Group. Blood Cancer J. 2022;12(8):119. PMID: 3598203.

Monoclonal gammopathy of clinical significance (MGCS)

Fermand JP, Bridoux F, Dispenzieri A, Jaccard A, Kyle RA, Leung N, et al. Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications. Blood. 2018;132(14):1478-85. PMID: 30012636.

MGUS in renal patients

Parry HM, Pratt G, Hutchison CA. Monoclonal gammopathy of undetermined significance: an update for nephrologists. Adv Chronic Kidney Dis. 2012 Sep;19(5):291-6. doi: 10.1053/j.ackd.2012.07.006. Review. PMID: 22920639.